assessment of the effect of nitric oxide within hippocampal ca1 area on spatial learning and memory in morphine dependent rats
Authors
abstract
introduction: there are evidences showing the role of nitric oxide in the opiate reward properties. the role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal ca1 area of rats is also confirmed. it has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of nmda receptors located in hippocampal ca1 area of rats. the effect of nitric oxide within hippocampal ca1 area on the spatial learning and memory processes in morphine dependent rats is unclear. methods: 33 n-mri male rats (250-350 g) were divided into 4 experimental groups. two cannulae were stereotaxically implanted bilaterally into hippocampal ca1 area. after 5 days recovery, animals received morphine sulfate or sucrose for 30 consecutive days in drinking water. morris water maze (mwm) studies were performed from day 26 to 30. in this period animals received bilateral intra-hippocampal ca1 injection of 3μg/ 2 μl l-name (nos inhibitor) or 2 μl saline (1 μl/site), 1 min before daily experimentation. spatial learning and memory parameters were subjected to analysis of variance (anova). results: morphine dependence facilitated spatial learning and memory in rats. this effect was inhibited with local administration of l-name in hippocampal ca1 area. conclusion: activation of intracellular no signaling pathway in the pyramidal cells of hippocampal ca1 area may involve in facilitating spatial learning and memory in morphine dependent rats.
similar resources
Assessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats
Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...
full textAssessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats
Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of NMDA...
full textNitric oxide within the rat hippocampal CA1 area may play a role in morphine tolerance
Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...
full textNitric oxide within the rat hippocampal CA1 area may play a role in morphine tolerance
Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...
full textAssessment of the role of NMDA receptors located in hippocampal CA1 area on the effects of oral morphine dependency on spatial learning and memory in rat
Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recover...
full textMy Resources
Save resource for easier access later
Journal title:
physiology and pharmacologyجلد ۱۱، شماره ۴، صفحات ۲۵۲-۲۶۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023